{"title":"Vegan PDRN","description":"\u003cp\u003eVegan PDRN uses plant- and ferment-derived polynucleotides to offer the renewing, hydrating benefits associated with PDRN, without any animal-derived ingredients. It is a thoughtful choice for those who prefer plant-based skincare.\u003c\/p\u003e\n\u003cp\u003eThis collection gathers vegan PDRN serums and creams from our curated brands. Explore more \u003ca href=\"\/collections\/vegan-skincare\"\u003evegan skincare\u003c\/a\u003e, build a routine for \u003ca href=\"\/collections\/wrinkles-aging\"\u003ewrinkles and fine lines\u003c\/a\u003e, or compare with classic \u003ca href=\"\/collections\/pdrn\"\u003ePDRN\u003c\/a\u003e.\u003c\/p\u003e","products":[{"product_id":"dr-althea-reju-5000-cream","title":"Dr. Althea Reju 5000 Cream","description":"\u003cp\u003e\u003cstrong\u003eSkin-Nomad's Take — At a Glance\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSoothing gel-cream that calms and strengthens the barrier\u003c\/li\u003e\n\u003cli\u003eVegan PDRN and 5% Centella water with triple hyaluronic acid\u003c\/li\u003e\n\u003cli\u003eFor sensitive, redness-prone and dehydrated skin\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSkin that reddens easily needs its barrier rebuilt more than it needs another calming ingredient laid over the top. The Dr. Althea Reju 5000 Cream leads with Centella Asiatica leaf water at 50,000ppm and a triple hyaluronic acid blend, the work of a South Korean derma brand that formulates around recovery rather than results by Friday.\u003c\/p\u003e\n\u003ch3\u003eKey Benefits\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentella Asiatica calms the response that shows up as redness:\u003c\/strong\u003e At 50,000ppm, Centella leaf water is the base this gel-cream is built on, settling the inflammatory activity in skin that has been over-stimulated. Skin that stings after cleansing quietens instead of flushing further.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThree weights of hyaluronic acid hold water at different depths:\u003c\/strong\u003e High and low molecular weight forms sit at different levels of the upper skin while the hydrolysed form travels furthest, so hydration is distributed rather than parked on the surface. Comfort lasts through the day instead of fading an hour after application.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBehind them sit ferment-derived PDRN and rhEGF, both chosen for repair:\u003c\/strong\u003e The PDRN here is made by ferment rather than drawn from salmon and sits at 5,000ppm alongside rhEGF, a growth factor whose reputation, like PDRN's, was built in injectable and wound-repair medicine where recovery is the whole point. Bringing that pairing into a cream you reach for every morning is the newer move, and the topical research on both is still being written.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eTexture \u0026amp; Finish\u003c\/h3\u003e\n\u003cp\u003eIt behaves like a jelly rather than a cream, breaking to water on contact and vanishing in a few seconds. Nothing is left sitting on the surface to pill or slide, so sunscreen and makeup go on over it cleanly.\u003c\/p\u003e\n\u003ch3\u003eIdeal For\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin types:\u003c\/strong\u003e All skin types, including normal, dry, combination and skin that reddens easily.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin concerns:\u003c\/strong\u003e Redness, stinging and tightness, a worn-down barrier, dehydration and early loss of firmness.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest used by:\u003c\/strong\u003e If you have been reaching for a soothing cream every few weeks and the redness keeps coming back, this is the one built to break that cycle.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eFAQ\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is ferment-derived PDRN the same as the salmon kind?\u003c\/strong\u003e\u003cbr\u003eA: They are the same class of ingredient reached by two different routes. Salmon PDRN is purified from fish DNA, while this version is produced by ferment, arriving at the same class of DNA fragment without an animal input. Topical research sits at a similar stage for both, so the useful thing to compare is the level stated on the box rather than the origin of the raw material.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How is it different from a basic soothing cream?\u003c\/strong\u003e\u003cbr\u003eA: A basic soothing cream comforts the surface, and the effect ends when it wears off. The Dr. Althea Reju 5000 Cream is aimed at the barrier itself, with hydration placed at three depths and a repair-focused pair of actives on top, so the goal is skin that reacts less next month rather than skin that feels better for an hour.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can I use this alongside retinoids or exfoliating acids?\u003c\/strong\u003e\u003cbr\u003eA: Yes. It takes the moisturiser slot, going on after cleansing, toner and any serum, and under sunscreen in the morning. Because it is built on Centella and hyaluronic acid rather than acids of its own, it does not compete with a retinoid or exfoliant used earlier, and it is a sensible thing to land on once those have left skin tender.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can I use the Reju 5000 Cream during pregnancy?\u003c\/strong\u003e\u003cbr\u003eA: We recommend pausing it. The rhEGF in the formula, listed as sh-Oligopeptide-1, is a newer skincare ingredient with no clinical safety data in pregnancy. The vegan PDRN, Centella and hyaluronic acid are not the concern; the growth factor alone is what makes this a cream to set aside until afterwards.\u003c\/p\u003e\n\u003cp\u003eThe 5,000 in the name is the PDRN, and the quieter number is the Centella at ten times that, which is what lets a repair cream be one you can wear every single day.\u003c\/p\u003e\n\u003cdiv class=\"sn-explore-more\"\u003e\n\u003cp\u003eExplore the \u003ca class=\"sn-ilink\" href=\"\/collections\/centella-asiatica\"\u003ecentella asiatica collection\u003c\/a\u003e for complementary soothing treatments to pair with this cream.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca class=\"sn-ilink\" href=\"\/collections\/centella-asiatica\"\u003eCentella asiatica\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca class=\"sn-ilink\" href=\"\/collections\/sensitive-skin\"\u003eSensitive skin\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca class=\"sn-ilink\" href=\"\/collections\/dr-althea\"\u003eMore from Dr. Althea\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n","brand":"Dr. Althea","offers":[{"title":"Default Title","offer_id":55245936001358,"sku":"DRAS01-CRrj","price":19.9,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0798\/5057\/0062\/files\/DRAS01-CRrj.png?v=1778671451"},{"product_id":"dr-althea-345-relief-cream","title":"Dr.Althea 345 Relief Cream","description":"\u003cp\u003e\u003cstrong\u003eSkin-Nomad's Take — At a Glance\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCalming gel-cream that soothes redness and sensitised skin while rebuilding the barrier\u003c\/li\u003e\n\u003cli\u003ePDRN, Centella Asiatica, Ceramide NP and triple-form hyaluronic acid in one lightweight formula\u003c\/li\u003e\n\u003cli\u003eFerment-derived vegan PDRN rather than the salmon form most PDRN skincare uses\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIf your skin flushes easily and you have never got on with either a heavy cream or a bare gel, this one is aimed at the gap between them. The Dr.Althea 345 Relief Cream is a gel-cream built on tea tree leaf water rather than plain water, with Centella Asiatica and Madecassoside on the redness and Ceramide NP holding the barrier underneath. Dr.Althea formulates in South Korea as a vegan brand throughout, on the principle that calming skin and rebuilding it are one job rather than two.\u003c\/p\u003e\n\u003ch3\u003eKey Benefits\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRedness is worked on at the base of the formula, not only on top of it:\u003c\/strong\u003e Tea tree leaf water stands in for plain water as the base, and Centella Asiatica, Madecassoside and Beta-Glucan settle the flare-ups above it. Reactive skin reads noticeably quieter within a few days of consistent use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCeramide NP reinforces the skin's lipid barrier:\u003c\/strong\u003e Panthenol works alongside it while three forms of hyaluronic acid, Sodium Hyaluronate, Hydrolysed Hyaluronic Acid and Polyquaternium-51, bind water at different depths. Less water escapes, so the calm holds well past the hour after application.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhere Niacinamide earns its place is tone and oil:\u003c\/strong\u003e \u003ca href=\"\/collections\/niacinamide\" class=\"sn-ilink\"\u003eNiacinamide\u003c\/a\u003e limits how much pigment reaches the surface cells and keeps oil production steady without stripping the skin. Dark marks fade on roughly the same timeline as the redness settles.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdding PDRN gives the formula a repair mechanism as well as a calming one:\u003c\/strong\u003e Dr.Althea are a vegan brand and describe the \u003ca href=\"\/collections\/vegan-pdrn\" class=\"sn-ilink\"\u003ePDRN\u003c\/a\u003e they use as ferment-derived rather than drawn from the salmon milt most PDRN skincare relies on. It brings a repair function that is neither calming nor lipid replacement, which is why it sits alongside the Centella and the Ceramide NP rather than duplicating either. PDRN's clinical reputation was built on the injectable, salmon-derived form used in wound-healing medicine, and topical research on the ferment-derived versions is the newer and still-developing side of it.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eTexture \u0026amp; Finish\u003c\/h3\u003e\n\u003cp\u003eA gel-cream that goes on cool and sinks in fast enough that oily and combination skin will not feel a film left behind, while dry skin gets enough substance from it to want nothing over the top. In weight it sits somewhere between a sleeping mask and a daily moisturiser.\u003c\/p\u003e\n\u003ch3\u003eIdeal For\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin types:\u003c\/strong\u003e All skin types, including oily, combination, dry, and skin prone to redness or irritation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin concerns:\u003c\/strong\u003e Redness, sensitivity, a barrier that has stopped coping, dehydration, uneven tone and congestion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest used by:\u003c\/strong\u003e If your skin is oily and reactive at once, or you are rebuilding after a run of \u003ca href=\"\/collections\/retinol\" class=\"sn-ilink\"\u003eretinoids\u003c\/a\u003e or acids, this gel-cream is built for exactly that awkward middle.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eFAQ\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How is this different from a standard calming moisturiser?\u003c\/strong\u003e\u003cbr\u003eA: The 345 in the name is a count of what is inside it: three calming botanicals, four barrier actives and five hydrating agents. The practical difference is that redness, barrier repair and water retention are handled in one step instead of being split between a soothing cream and a richer one. The gel texture is what stops oily skin paying for that breadth in weight.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is the PDRN in this cream the same as the salmon PDRN in most K-beauty?\u003c\/strong\u003e\u003cbr\u003eA: No, and it is the reason this one can carry a vegan badge. Most topical PDRN is polydeoxyribonucleotide isolated from salmon milt, whereas Dr.Althea are a vegan brand throughout and describe their PDRN as ferment-derived, produced from fermented ingredients rather than an animal source. It appears on the ingredient list as Sodium DNA either way, so the label alone will not tell you which a product contains; the brand's own statement is what settles it.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Does the tea tree base make this a spot product?\u003c\/strong\u003e\u003cbr\u003eA: No. What is in the formula is tea tree leaf water used as the base in place of plain water, which brings the plant's calming character without the dryness people associate with tea tree oil. The Dr.Althea 345 Relief Cream is a daily moisturiser for reactive skin rather than a targeted blemish product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can I use this cream while pregnant?\u003c\/strong\u003e\u003cbr\u003eA: Yes. It carries our Pregnancy Safe badge, based on a review of the full ingredient list against published clinical guidance. There is no retinoid, no hydroquinone and no oxybenzone in the formula. The calming work is done by Centella Asiatica with Madecassoside, Tea Tree leaf water, Panthenol, Beta-Glucan and Ceramide NP, with Niacinamide for tone, and none of these carry a contraindication in the guidance we review against. Worth knowing that the route here is Centella rather than an acid, which is part of why it suits a stretch when skin tends to react more than usual. Our method and sources are on our \u003ca href=\"\/pages\/pregnancy-safe-skincare\"\u003epregnancy safe skincare page\u003c\/a\u003e. This is not medical advice, so if you are using prescription skincare or have a specific concern, speak to your midwife or GP first.\u003c\/p\u003e\n\u003cp\u003eThe point at which this cream proves itself is not the flare-up but the ordinary week six weeks later, when there is nothing left to calm and you are still reaching for it.\u003c\/p\u003e\n\u003cp class=\"sn-explore-more\"\u003e\u003cstrong\u003eExplore more\u003c\/strong\u003e\u003cbr\u003eBrowse more \u003ca href=\"\/collections\/vegan-pdrn\"\u003eVegan PDRN\u003c\/a\u003e, see what suits \u003ca href=\"\/collections\/sensitive-skin\"\u003esensitive skin\u003c\/a\u003e, or explore the full \u003ca href=\"\/collections\/dr-althea\"\u003eDr. Althea\u003c\/a\u003e range.\u003c\/p\u003e","brand":"Dr. Althea","offers":[{"title":"Default Title","offer_id":59873169965390,"sku":"DRAS01-CRRR","price":22.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0798\/5057\/0062\/files\/DRAS01-CRRR.png?v=1781890504"},{"product_id":"lilyeve-scalp-turn-cica-pdrn-brush-ampoule","title":"lilyeve Scalp:Turn CICA PDRN Brush Ampoule","description":"\u003cp\u003e\u003cstrong\u003eSkin-Nomad's Take — At a Glance\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eClimbazole and piroctone olamine with Salicylic Acid at the scalp\u003c\/li\u003e\n\u003cli\u003eHydrolysed DNA, the ingredient the PDRN in the name refers to\u003c\/li\u003e\n\u003cli\u003eWatery, brush-applied, and dry within a couple of minutes\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eA flaking, itching scalp is usually treated as a dryness problem and moisturised, which is why it tends to come back. lilyeve treats it as skin with a yeast and sebum problem instead, putting climbazole and piroctone olamine against the organism and salicylic acid against the build-up it feeds on. This is the Scalp:Turn end of the range, where the work is done on the skin rather than the strand.\u003c\/p\u003e\n\n\u003ch3\u003eKey Benefits\u003c\/h3\u003e\n\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eClimbazole and piroctone olamine go after the yeast, not the flake.\u003c\/strong\u003e Both are antifungal actives that reduce the Malassezia yeast living on scalp oil, which is what sets off the itch and the flaking behind it. That is a different job from softening flakes with a moisturiser, because scalp flaking of this kind is a reaction rather than a dryness problem.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSalicylic Acid reaches the follicle opening because it dissolves in oil.\u003c\/strong\u003e It moves through sebum instead of being repelled by it, so it loosens the plug of oil and dead skin at the mouth of the follicle rather than only lifting the flat surface between hairs. A clear opening is the difference between an ampoule that reaches the root and one that sits on top of the build-up.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHydrolysed DNA is the repair half, and the newest thing in the bottle.\u003c\/strong\u003e PDRN reached beauty from clinical repair work, where the molecule is placed beneath the skin; topical study, where it has to work from the surface, is newer and still developing. Its job here is the state the skin is left in once the flaking stops, which is not something an antifungal covers.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe calming comes from a herbal complex rather than from Centella.\u003c\/strong\u003e Despite the CICA in the name, there is no Centella Asiatica on the ingredient list. What is there is neem leaf and flower high up the formula, then heartleaf, chamomile, rosemary, lavender, sage, thyme and a dozen more running through the back half. It is breadth rather than one named soother, and worth knowing if Centella is specifically what you were after.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eTexture \u0026amp; Finish\u003c\/h3\u003e\n\n\u003cp\u003eAlcohol Denat. sits second on the list, so the fluid is watery and quick, drying in a couple of minutes and leaving nothing to comb out. The brush head parts the hair so it lands on skin rather than soaking into the lengths, and hair does not look greasy or separated afterwards. Menthol and Eucalyptus Globulus leaf oil give it a strong cold hit going on.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eNote:\u003c\/strong\u003e Between the alcohol base, the menthol and two antifungal actives, a scalp that is already raw will feel this more than a comfortable one. The flaking and itch also settle well before anything about the hair itself looks different.\u003c\/p\u003e\n\n\u003ch3\u003eIdeal For\u003c\/h3\u003e\n\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHair types:\u003c\/strong\u003e Any hair type or curl pattern, on scalps that turn oily and build up between washes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHair concerns:\u003c\/strong\u003e Flaking and itch, sebum build-up around the roots, and scalp comfort between washes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest used by:\u003c\/strong\u003e People who have been moisturising a flaking scalp for months and getting nowhere, because the cause was never dryness.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eFAQ\u003c\/h3\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: How is this different from an anti-dandruff shampoo?\u003c\/strong\u003e\u003cbr\u003eA: A medicated shampoo carries similar antifungal actives, but it is on the scalp for the length of a wash and then rinsed away. This is left on, so climbazole, piroctone olamine and salicylic acid stay in contact with the skin until the next wash. That contact time is the whole argument for the format, and it is also why the alcohol base is worth taking seriously.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What is PDRN, and where is it on the ingredient list?\u003c\/strong\u003e\u003cbr\u003eA: It appears as Hydrolyzed DNA. PDRN is a DNA-fragment ingredient whose reputation was built in injectable and wound-healing use, where it is placed beneath the skin, and the topical version of that story is newer and still being worked out. Pairing it with the herbal complex tells you what it is in for: both are aimed at the state the scalp is left in once the yeast and the sebum plug are dealt with.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: Can I use it alongside a caffeine shampoo, and how often?\u003c\/strong\u003e\u003cbr\u003eA: Yes, there is no interaction between a rinse-off shampoo and a leave-on ampoule, and lilyeve puts this at morning and evening on damp scalp after washing. If you use other exfoliating or antifungal scalp products, alternate rather than layering them on the same day, because doubling salicylic acid on the scalp buys irritation rather than a faster result.\u003c\/p\u003e\n\n\u003cp\u003eHair looks better when the skin it grows out of stops being irritated, which is a duller sentence than the one on the front of the bottle and a more dependable one.\u003c\/p\u003e\n\n\u003cp class=\"sn-explore-more\"\u003e\u003cstrong\u003eExplore more\u003c\/strong\u003e\u003cbr\u003eBrowse more \u003ca href=\"\/collections\/hair-care\"\u003ehair care\u003c\/a\u003e, or see the full \u003ca href=\"\/collections\/lilyeve\"\u003elilyeve\u003c\/a\u003e range.\u003c\/p\u003e","brand":"lilyeve","offers":[{"title":"Default Title","offer_id":59873194377550,"sku":"LIVHS02-SR","price":25.9,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0798\/5057\/0062\/files\/LIVHS02-SR_daaeba81-9d83-46fd-92b3-cbb209712218.png?v=1781890452"}],"url":"https:\/\/skinnomid.com\/collections\/vegan-pdrn.oembed","provider":"Skin-Nomad","version":"1.0","type":"link"}