{"product_id":"centellian24-expert-madeca-cream-active-renew-pdrn","title":"Centellian24 Expert Madeca Cream Active Renew PDRN","description":"\u003cp\u003e\u003cstrong\u003eSkin-Nomad's Take — At a Glance\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eTECA-PDRN complex at 20,000 ppm, with pure PDRN at 2,000 ppm\u003c\/li\u003e\n\u003cli\u003eMadecassic acid at 1,600 ppm and nine forms of \u003ca class=\"sn-ilink\" href=\"\/en-ca\/collections\/hyaluronic-acid\"\u003ehyaluronic acid\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eA rich, scented night cream for mature and barrier-worn skin\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSkin that has turned tight, quick to redden and slower to bounce back is telling you about its barrier before anything else. Centellian24 Expert Madeca Cream Active Renew PDRN answers that with what the brand calls its TECA-PDRN complex at 20,000 ppm: madecassic acid at 1,600 ppm, the isolated \u003ca class=\"sn-ilink\" href=\"\/en-ca\/collections\/centella-asiatica\"\u003eCentella\u003c\/a\u003e compound their research is founded on, and pure PDRN at 2,000 ppm for the repair side that calming alone does not reach. Centellian24 came out of Dongkook Pharmaceutical's dermatology unit, which is why the Centella arrives as a named compound at a stated dose rather than as a plant on the label.\u003c\/p\u003e\n\u003ch3\u003eKey Benefits\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMadecassic acid at 1,600 ppm does the structural work:\u003c\/strong\u003e Together with asiaticoside and asiatic acid, both named separately on the list, it strengthens barrier function and calms the reactivity that comes with a barrier under strain. Tightness and sensitivity drop away with continued use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe PDRN here is drawn from five sources, not one:\u003c\/strong\u003e Centellian24 describe it as 5D-PDRN, taken from Centella, salmon, rose, marine sources and houttuynia, and declare the pure fraction at 2,000 ppm as Sodium DNA. PDRN acts on adenosine A2A receptors at the skin surface, the pathway through which the skin's own repair signalling is switched on, and that activity is what built its name across years of clinical and injectable work. Bringing it into a daily cream is the newer step and the topical research is still growing, which is exactly why a stated dose at this level is worth reading. It is not vegan, because salmon is one of the five.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNine forms of hyaluronic acid is not a marketing count:\u003c\/strong\u003e Sodium hyaluronate, hyaluronic acid itself, a crosspolymer, two hydrolysed forms, potassium hyaluronate and three silanol and cationic variants each behave differently on the skin, binding water at different depths and clinging to it for different lengths of time. Niacinamide reinforces the skin's own lipid production underneath them.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlushing and visible redness get actives of their own:\u003c\/strong\u003e Caffeine constricts the small vessels near the surface, glutathione and ascorbic acid work the oxidative side of tone, and Rosa Damascena flower water sits high on the list calming the skin they act on. Colour settles rather than being buried under moisture.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eTexture \u0026amp; Finish\u003c\/h3\u003e\n\u003cp\u003eIt is a proper cream in weight, closer to a night cream than to a daily gel, and it settles to a soft, sealed finish rather than a matte one. On dry and mature skin that weight is the point, because holding water in place is half of what a barrier cream exists to do.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNote:\u003c\/strong\u003e This is a scented cream. Lavender, bergamot, orange peel, rosemary and chamomile oils sit in the formula with limonene and linalool declared as allergens, so skin that reacts to aromatic plants should patch test rather than rely on the Centella content. Combination skin with dry patches will also find this better suited to evenings than to a summer morning.\u003c\/p\u003e\n\u003ch3\u003eIdeal For\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin types:\u003c\/strong\u003e Mature, dry and barrier-worn skin, plus combination skin with dry patches. Fragrance-sensitive skin should look elsewhere in the range.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin concerns:\u003c\/strong\u003e Loss of firmness and elasticity, fine lines, persistent dryness, tightness and redness.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest used by:\u003c\/strong\u003e Someone in their forties or beyond whose skin has stopped tolerating the actives it used to will find this a way back to comfort without giving up on results.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eFAQ\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How is this different from a lightweight Centella serum?\u003c\/strong\u003e\u003cbr\u003eA: A Centella serum delivers the calming compounds and very little else, which is the right choice on skin that is only irritated. This pairs madecassic acid at 1,600 ppm with nine hyaluronic acids and a rich base, so the same soothing arrives with the water and the seal that barrier-worn skin also needs. If serums have calmed your skin without stopping it feeling tight, the richer format is the part that has been missing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Does PDRN in a cream do what an injectable PDRN treatment does?\u003c\/strong\u003e\u003cbr\u003eA: No, and it is worth being clear about that. An injection places the molecule beneath the skin surface, whereas a cream works from the outside in, and results from one format do not transfer to the other. Applied to the surface it works on the same repair signalling from the outside, on a timescale of weeks rather than days, which is a different rhythm from the comfort the Centella and the hyaluronic acids deliver on day one.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Where does a cream this rich go in a routine?\u003c\/strong\u003e\u003cbr\u003eA: It is the last skincare step in the evening, after cleansing, any toner or essence, and your treatment step. In the morning it goes under sunscreen, which stays the final skincare step of all. It is a complete moisturising layer on its own, so nothing needs to go over it at night.\u003c\/p\u003e\n\u003cp\u003ePrinting the ppm figures on the front is a small thing, and it tells you Centellian24 expect the people buying this cream to check them.\u003c\/p\u003e\n\u003cp class=\"sn-explore-more\"\u003e\u003cstrong\u003eExplore more\u003c\/strong\u003e\u003cbr\u003eExplore the \u003ca href=\"\/en-ca\/collections\/centella-asiatica\"\u003eCentella Asiatica\u003c\/a\u003e collection, target \u003ca href=\"\/en-ca\/collections\/wrinkles-aging\"\u003ewrinkles \u0026amp; fine lines\u003c\/a\u003e, or see more from \u003ca href=\"\/en-ca\/collections\/centellian24\"\u003eCentellian24\u003c\/a\u003e.\u003c\/p\u003e","brand":"Centellian24","offers":[{"title":"Default Title","offer_id":59872798703950,"sku":"CTS12-C","price":27.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0798\/5057\/0062\/files\/CTS12-C.png?v=1781890652","url":"https:\/\/skinnomid.com\/en-ca\/products\/centellian24-expert-madeca-cream-active-renew-pdrn","provider":"Skin-Nomad","version":"1.0","type":"link"}